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Strategies for the design of hydrophilic matrix tablets with …

Release profiles of the incorporated pH modifiers in addition to the microenvironmental pH (pH M) should also be investigated. We have demonstrated that the choice of an ideal pH modifying agent is crucial since the effect and duration of acidification strongly depends on the type of the incorporated pH modifier.

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Frontiers | Molecular Approaches for Low-Cost Point-of-Care …

The first report describing a complete protocol for plant pathogen detection that could be performed directly in the field dates back to 2005, and the DNA was extracted modifying a commercial kit in order to avoid the use of liquid nitrogen and laboratory equipment, such as centrifuge and vortex (Tomlinson et al., 2005).

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Viscosity Modifying Admixtures

By Ara A. Jeknavorian, Ph.D. Most concrete producers readily associate viscosity-modifying admixtures (VMAs) with the manufacture and placement of underwater concrete (UWC) and self-consolidating concrete (SCC), two of the earliest applications for this relatively new type of chemical admixture. VMAs, by virtue of their …

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Neutralization and co-precipitation of heavy metals by

The recovered water can be reused in other mining processes or in agriculture. ... the neutralization of an effluent was studied by progressive addition of lime as a pH-modifying agent. Batch and continuous tests were conducted to evaluate the neutralization potential between pH 1 and 11 on an effluent containing As, Cu, Fe, Zn, Ni, …

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Effect of alkalizing agent on abuse deterrent potential of multiple

Various alkalizing agents, such as magnesium hydroxide, aluminum hydroxide, calcium carbonate, and calcium hydroxide, formulated in pH modifying layer, respectively, were evaluated based on in-vitro drug release studies carried out in FaSSGF for 2 h followed by FaSSIF for additional 22 h. The drug release profiles from 1-, 3- and 5 …

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Chelating agents for oilfield stimulation: Lessons learned and …

A weakly alkaline chelating agent (pH = 10–11) was implemented in an offshore oilfield in China with a reservoir temperature of 185 °C (Wang et al., 2019a). The treatment was done to produce a deep wormhole in a carbonate formation wherein conventional HCl treatment is highly detrimental to the tubular integrity and yields a face …

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Flotation Conditioners -Modifiers -Activators -Depressants

Activators will attach itself to the surface of the mineral to allowing other reagents to react to it. Depressants. This is a group of chemicals that react with the minerals to prevent them from floating with the collector. These four are the main classifications of mining reagents that we will deal with. There are others but they either are ...

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A novel oil-based suspension of a micro-environmental, pH-modifying

Micro-environmental pH-modifying solid dispersion (micro pHm SD) is an effective method for enhancing the dissolution of pH-dependent soluble APIs. However, erratic bioavailability of these drugs was often found when the micro pHm SD of the drugs was orally administrated and passed through the gastrointestinal tract.

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From initial treatment design to final disposal of chelating agents: …

The pH of the solution was shown to influence the degradability of the complex because higher pH values would result in the preferential formation of uncomplexable iron hydroxides. 138,142,143 Degradation of ferric NTA and EDTA chelates at 30 °C (86 °F) and pH 9–10 were observed to involve decarboxylation of the chelating agent and ...

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A review of Formulations of Commercially Available Antibodies

The pH range of commercially available antibody formulations is pH 4.8-8.0 and the buffers or pH-modifying agents include histidine, phosphate, citrate, acetate, succinate, lactic acid, tromethamine, aspartic acid, glutamate, adipic acid, and 2-(N-morpholino)-ethanesulfonic acid (MES).

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Introduction to Modifying Agent () |

More Modifying Agent sentence examples. 10.17650/1818-8346--64-72.,;,。. More Modifying Agent sentence examples. 10.1186/s13023-021-01862-w. 、 ...

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Population Pharmacokinetic Analysis of Itacitinib, a Selective JAK …

Co-administration of CYP3A4 inhibitors or inducers, P-gp inhibitors, and gastric pH modifying agents were also explored as time-variant covariates. Data and Results The final dataset contained 3686 PK samples from 321 participants, of which 55.1% were male, 85.4% were white, and the median age and body weight were 46 y and 77.7 …

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Water | Free Full-Text | Removal of Manganese(II) from Acid …

Many global mining activities release large amounts of acidic mine drainage with high levels of manganese (Mn) having potentially detrimental effects on the environment. This review provides a comprehensive assessment of the main implications and challenges of Mn(II) removal from mine drainage. We first present the sources of …

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Citric acid monohydrate as a release-modifying agent in melt …

Release of citric acid monohydrate (CA MH) from extruded Eudragit ® RS PO matrix tablets containing 60% polymer, 20% diltiazem hydrochloride and 20% CA MH. Dissolution: USP paddle method, 900 ml phosphate buffer pH 6.0 as dissolution medium, 37 °C, 50 rpm, n = 6.

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(PDF) Dissolution-modulating mechanism of pH …

It is believed that step-by-step mechanistic approaches could provide the ultimate solution for solubilizing several poorly water-soluble drugs with pH-dependent solubility from a solid...

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Bone-Modifying Agents: Complicated to Use | JCO Oncology …

Initiation of the bone-modifying agent should be delayed until necessary preventive dental work is completed. 2,3 During the period of bone-modifying agent use, regular follow-up with a dental professional should be encouraged, and invasive dental procedures should be avoided, although cleaning, crown placement, or cavity repair can …

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pH Adjustment and Neutralization, the basics

An increase of 1 pH unit requires 1/10th the amount of caustic required to achieve the previous increase. Descending from 7.0 to 0.0, each unit on the pH scale represents a ten fold increase in acidity. In simple terms, very large volumes of a neutralizing agent are required to achieve very small results at high or low pH values.

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Reducing Agent

In addition to the various reducing agents, including sugars, metal based reducing agents Sn II, Cu 0, or a clean single electron reducing agent Ag 0, 161 initially added to activate and reactivate the Cu II complex in AGET and ARGET initiating systems, one can include addition of many specific reagents (also mild reducing agents) to modify K ...

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CN107955614A

A kind of Southern Red Soil modifying agent and its application method based on mining area tailings, belong to ecological environment recovery technique field, mix count by weight percentage by following material composition and uniformly:25% ~ 35% rare-earth mining area tailings, 15% ~ 25% zeolite and palygorskite mixture, 15% ~ 20% dry powder and …

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Mechanical properties improvement of chitosan films via the use …

Some researchers have reported that charge modifying agents such as NaCl could be used to achieve the aforementioned molecular structure modification objective (Klinkesorn and Namatsila, 2009). The structural change of the chains nevertheless depends on the ionic strength or concentration of a charge modifying …

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Chapter 7 MINING AGENT BEHAVIORS

to predict agent behavior, mapping the vector elements to agent actions. Let us consider an agent authorized to execute a number of functions on files, as determined by its action …

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Remediation of heavy metal contaminated soils by

1. Introduction. Soil polluted by heavy metals (HMs) is commonly exist in most areas of China, and concentrations of HMs, e.g., Cd, Cu, Pb and Zn in urban soils often exceed their background values (Wei and Yang, 2010).Sources of HMs in soil could be anthropogenic activities, such as mining and smelting (Li et al., 2014), wastewater …

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pH-sensitive Eudragit nanoparticles for mucosal drug delivery

Micro-environmental pH-modifying solid dispersion (micro pHm SD) is an effective method for enhancing the dissolution of pH-dependent soluble APIs. However, erratic bioavailability of these drugs was often found when the micro pHm SD of the drugs was orally administrated and passed through the gastrointestinal tract.

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China Modifying Agent Factory & Suppliers

Modifying Agent Manufacturers, Factory, Suppliers From China, Our company insists on innovation to promote the sustainable development of enterprise, and make us become the domestic high-quality suppliers. ... Sodium Carbonate: The Versatile pH Regula... Sodium carbonate, also known as soda ash, is a common chemical compound used in the …

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Hydrophobic agents and pH modification as comparative …

The photocatalytic activity was modified and improved in the HMDS-1 coating due to the hydrophobic agent and type of nanoparticles. To compare the effect …

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pH of Water

Instead, it is a figure between 0 and 14 defining how acidic or basic a body of water is along a logarithmic scale ¹. The lower the number, the more acidic the water is. The higher the number, the more basic it is. A pH of 7 …

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Genome mining unveils a class of ribosomal peptides with two …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) constitute a major family of natural products present in all domains of life 1, 2. RiPP biosynthesis starts with the ...

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Engineering Proceedings | Free Full-Text | pH Variation during

The pH was measured at weekly intervals, starting immediately after the addition of a spore suspension into the medium, and continuing on days 3, 10, 17, 24, and 30. Figure 1 illustrates the pH course in the media containing specific metal ions and the microscopic fungus. The pH values were plotted against time, providing insights into the ...

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Improving Dissolution Behavior and Oral Absorption of …

A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability, low-solubility, and weak base) drugs under high gastric pH due to the disease …

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Design of pH-independent controlled release matrix tablets for …

A commonly used approach to enhance the dissolution of drugs with pH-dependent solubility is the incorporation of pH modifiers. The aim of this study was to evaluate the duration and extent of pH modifying effect on the micro-environmental pH in HPMC matrix by applying two mechanistic approaches regarding hydrodynamic stress …

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